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Free MPJE Practice Questions

10 free, exam-style Multistate Pharmacy Jurisprudence Examination (MPJE) practice questions with answers and explanations. No signup required. Work through them below, then take the full free MPJE practice test to study every exam domain.

Question 1

A prescription for oxycodone 30 mg is presented with DEA number BE4291673 for Dr. Lisa Evans. Using the DEA check-digit algorithm, the pharmacist determines this number is:

  1. Valid - the second letter matches the prescriber's last name initial and the check digit is correct
  2. Valid - the first letter confirms this is a practitioner-type registration
  3. Invalid - the check digit does not match
  4. Invalid - the second letter should reflect the prescriber's first name initial, not last name initial
Show answer & explanation

Correct answer: C - Invalid - the check digit does not match

Question 2

As pharmacist-in-charge, you discover during a routine audit that 200 tablets of oxycodone are unaccounted for. Under 21 CFR 1301.76(b), what is the FIRST required action?

  1. Conduct a thorough internal investigation and document all findings before notifying any external agency
  2. Notify the DEA with a preliminary report within 1 business day
  3. Submit DEA Form 41 to document and authorize the disposal of remaining controlled substance inventory
  4. File a complete DEA Form 106 within 7 calendar days of discovering the discrepancy
Show answer & explanation

Correct answer: B - Notify the DEA with a preliminary report within 1 business day

Question 3

A physician calls the pharmacy at 8 PM to verbally authorize an emergency dispensing of oxycodone 10 mg #20 for a post-surgical patient. The pharmacist dispenses the medication. Under 21 CFR 1306.11(d), what must the prescriber provide, and by when?

  1. A verbal follow-up within 24 hours and a written prescription within 30 days of the emergency dispensing
  2. A written or EPCS prescription within 7 days, marked 'Authorization for Emergency Dispensing'
  3. A complete written prescription within 72 hours, referencing the original emergency oral authorization
  4. No follow-up is required if the pharmacist documents the emergency dispensing in the patient's profile
Show answer & explanation

Correct answer: B - A written or EPCS prescription within 7 days, marked 'Authorization for Emergency Dispensing'

Question 4

Federal law does not specify an expiration date for Schedule II prescriptions. A patient presents a written CII prescription dated 8 months ago. Your state requires CII prescriptions to be filled within 6 months of the issue date. The pharmacist should:

  1. Refuse to fill the prescription; the stricter state standard applies
  2. Fill the prescription, as federal law governing CII prescriptions does not impose an expiration date
  3. Contact the DEA for a ruling on which standard applies in this jurisdiction
  4. Fill a 30-day emergency supply while requesting the prescriber issue a new prescription
Show answer & explanation

Correct answer: A - Refuse to fill the prescription; the stricter state standard applies

Question 5

A pharmacist receives a call from a patient's cardiologist requesting the patient's complete medication list to prepare for an upcoming cardiac procedure. The patient is not present. Under HIPAA, the patient's written authorization:

  1. Is not required only if the patient previously signed a HIPAA acknowledgment form at registration
  2. Is required for any prescription medication, regardless of the purpose of disclosure
  3. Is required, because the cardiologist is not part of the same covered entity as the pharmacy
  4. Is not required; this disclosure is permitted under HIPAA's treatment exception
Show answer & explanation

Correct answer: D - Is not required; this disclosure is permitted under HIPAA's treatment exception

Question 6

A patient presents a written CII prescription dated January 1st. On January 15th, the pharmacist partially fills it at the patient's request. On February 2nd - 32 days after the prescription was written - the patient returns for the remainder. The pharmacist should:

  1. Dispense the remainder; 30 days is measured from the date of the first partial fill, not the written date
  2. Dispense a 7-day emergency supply and request a new prescription for any remaining quantity
  3. Refuse to dispense; the 30-day CARA window runs from the date the prescription was written
  4. Dispense the full remainder; 60 days applies to all patient-requested Schedule II partial fills
Show answer & explanation

Correct answer: C - Refuse to dispense; the 30-day CARA window runs from the date the prescription was written

Question 7

Which of the following prescription medications is EXEMPT from child-resistant packaging requirements under the Poison Prevention Packaging Act?

  1. Alprazolam 0.5 mg tablets
  2. Hydrocodone/acetaminophen 5/325 mg tablets
  3. Atorvastatin 20 mg tablets
  4. Sublingual isosorbide dinitrate 5 mg tablets
Show answer & explanation

Correct answer: D - Sublingual isosorbide dinitrate 5 mg tablets

Question 8

A patient presents a prescription for oxycodone 30 mg #120 from a physician located 85 miles away, requests to pay cash, and mentions she drove past several pharmacies to reach yours. Under 21 CFR 1306.04, the pharmacist's MOST appropriate action is:

  1. Verify the prescription's legitimacy with the prescriber and check the PMP before dispensing
  2. Fill the prescription, as the pharmacist's corresponding responsibility only applies to visibly altered or forged prescriptions
  3. Refuse to fill and confiscate the prescription, then notify the DEA immediately
  4. Dispense a 72-hour supply as a good-faith interim measure while attempting to reach the prescriber
Show answer & explanation

Correct answer: A - Verify the prescription's legitimacy with the prescriber and check the PMP before dispensing

Question 9

A pharmacy discovers that 45 tablets of lorazepam (Schedule IV) are missing following a monthly inventory reconciliation. Which DEA form is required, and what is the deadline for electronic submission?

  1. DEA Form 41; document within 15 business days of discovery
  2. DEA Form 106; submit electronically within 15 calendar days
  3. DEA Form 222; notify the primary supplier within 7 calendar days
  4. DEA Form 224a; file an amendment within 30 days of the next renewal period
Show answer & explanation

Correct answer: B - DEA Form 106; submit electronically within 15 calendar days

Question 10

A health system wants to prepare large batches of IV bags without patient-specific prescriptions to stock in surgical suites for anticipated patient needs. To do this legally, the compounding facility must:

  1. Obtain a state board bulk compounding authorization under Section 503A of the FD&C Act
  2. Seek new drug application approval from the FDA for each anticipated compounded formulation
  3. Register as a Section 503B outsourcing facility with the FDA
  4. Apply to the DEA for a Schedule II bulk manufacturing license
Show answer & explanation

Correct answer: C - Register as a Section 503B outsourcing facility with the FDA

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